Table S2. Quality assessment score.

ParameterDescriptionValue
Minimizing selection bias
Study design
Unclear
Retrospective
Prospective, including partially prospective
0
1
2
Final cohort populationNot representative (only IAs of certain
location and rupture status)
Representative (IAs from different
locations and rupture status)

0

2
Minimizing information bias
Study period / years reportedNo
Yes		0
2
IA tissue collectionUnclear / Not reported
Intraoperatively, endovascular biopsy or mixed
Autopsy		0
1
2
Patient number3 - 9
10 - 49
50 and more		0
1
2
IA typeUnclear or mixed (saccular/non-saccular)
Only saccular
0
2
Population baseline characteristicsNo
Incomplete demographic and clinical data
Complete demographic and clinical data		0
1
2
Individual radiographic characteristics of IA (location, size, and morphology)No
Incomplete radiographic data
Complete radiographic data		0
1
2
Tissue workup method described
Not described
Described		0
2
Study goal / Statistical evaluationDescriptive data
Statistical analysis without adjustment for confounder
Statistical analysis with adjustment for confounder		0
1
2