Table S3. Estimation of the Level of Evidence for histological biomarkers

ClassDefinition
IHigh quality
1. Data from at least 2 good quality studies with ? 50 patients per study AND
2. Assessment of both main endpoints (differences UIA vs RIA AND IA vs control vessel) AND
3. Non-conflicting results from good quality studies
IIModerate quality
1. Evidence including data from at least 2 good quality studies with ? 50 patients (in sum) AND
2. Assessment of both main endpoints (differences UIA vs RIA AND IA vs. control vessel) AND
3. Non-conflicting results from good quality studies
IIILow quality
Summary data from:
1. >=100 patients regardless the study quality OR
2. >=50 patients from good quality studies
IVVery low quality
Any lower evidence for analyzed histological marker