Table S6. The full list of associations between the histological markers and secondary review endpoints

MarkerAbbreviationOther Endpoint
Histological markers
Heme Oxygenase 1HO1Associated with Wall Degeneration 064
Leukocyte common antigen CD45+CD45+Associated with Wall Degeneration 017, NO Associated between CD45+ and Foam Cells 031
Apolipoprotein AApoAAssociated with Macrophages 090
Apolipoprotein B100ApoB100Associated with Macrophages 090
Apolipoprotein EApoEAssociated with Macrophages 090
Mast Cells: Tryptase / ChymaseAA1/CC1Associated with Endothelium damage 087
Vascular Endothelial Growth Factor, incl. VEGF-R1/-R2VEGFVEGF-R1 Associated with remodeling, T cell & Macrophage infiltration, thrombus; VEGF-R2 Associated with hyperplasia & proliferation 030
IA biomechanicsIA stretching induces decrease of Collage types IV & VI and increase of MMP-1 & 3 072
MyeloperoxidaseMPOAssociated with Wall Inflammation & Degeneration 089
Oxidized low-density lipoproteinOxLDLAssociated with Loss of Mural Cells and Wall Degeneration 031
Glycophorin AGPA / GYPAAssociated with Wall Degeneration and inflammatory Cells 088
Endothelial layer (degeneration/destruction)Associated with Mast Cells 087 and Inflammation 017
Basic fibroblast growth factor inclusive receptor 1bFGF / bFGF-R1Associated with “Minor Leaks” 030
Smooth muscle cell layer lossAssociated with MPO 089
ThrombosisAssociated with VEGFR1 030, iron accumulation 045, MPO 089, inflammation 017, 111
Morphology IA characteristics (Size & irregularity)
Collagen(U)IA size was associated with Collagen content: The Larger IA, the more Collagen content 006, 080, 109
Endothelial layer (degeneration/destruction)Associated with IA Size 109
Smooth Muscle Cell layer lossAssociated 059 or NOT 080 Associated with IA size
Myointimal hyperplasiaAssociated with IA Size 102
Cys-His-rich proteinPINCHAssociated with UIA size, but not RIA size 091
Extracellular signal-regulated kinaseERKNOT Associated with IA size 063
High-mobility group box 1HMGB1NOT Associated with IA size 121
Krüppel-like zinc-finger transcription factor 5KLF5 / BTEB2 / IKLFAssociated with IA size 082
Macrophage M2 antigen CD86+CD86+Associated with IA size 080, 082
T-cells (CD45RO) & Lymphohistiocytic cells (CD45RB) antigensCD45RO / CD45RBAssociated with IA size 059
?-smooth muscle actin?-SMAAssociated with IA irregularity 089
Cathepsin B geneCTSBAssociated with IA size 006
Tissue inhibitor of metalloproteinase 4TIMP4Associated with IA size 006
Imaging findings (MRI & CFP)
Macrophage M2 antigen CD163+CD163+Associated with MRI finding 037
Platelet endothelial cell adhesion moleculePECAM 1 / CD31Associated with MRI finding 105
Prostaglandin E2 / microsomal Prostaglandin E2 Synthase-1PGE2 / mPGES-1Associated with ferrumoxitol-intake in MRI 037
Macrophage M2 antigen CD86+CD86+Associated with MRI finding 041, 105
Gylcophorin AGPA / GYPAAssociated with MRI finding 088
Cyclooxygenase-1, aka Prostaglandin G/H Synthase 1, Prostaglandin-endoperoxide Synthase 1, or Prostaglandin H2 Synthase 1COX-1 / PTGS1Associated with ferrumoxitol-intake in MRI 037
Cyclooxygenase-2, aka Prostaglandin-endoperoxide Synthase 2 (Prostaglandin G/H Synthase and cyclooxygenase)COX-2 / PTGS2Associated with ferrumoxitol-intake in MRI 037
Myointimal hyperplasiaAssociated with stable CFD flow values 017
ThrombosisAssociated with low minimum WSS / CFD measurements 017, 111
Diverse endpoints
CollagenAssociated with Carbon birth dating 025
Smooth muscle cell layer lossAssociated with Smoking 080
ThrombosisAssociated with the time left since IA clipping 024
Cyclooxygenase-1, aka Prostaglandin G/H Synthase 1, Prostaglandin-endoperoxide Synthase 1, or Prostaglandin H2 Synthase 1COX-1 / PTGS1NOT Associated with Aspirin 040
Cyclooxygenase-2, aka Prostaglandin-endoperoxide Synthase 2 (Prostaglandin G/H Synthase and cyclooxygenase)COX-2 / PTGS2Associated with Aspirin 040
Prostaglandin E2 / microsomal Prostaglandin E2 Synthase-1PGE2 /mPGES-1Associated with Aspirin 040